This collection consists primarily of correspondence, documents, photographs and memorabilia dating from Esther Winkler Shapiro’s service as a U.S. Army nurse on the Pacific front during the Second World War, with a smaller assortment of material dating from her time as a nursing student at The Mount Sinai Hospital School of Nursing. Memorabilia include a World War II Army Nurse Corps uniform and cap, a Japanese flag, and Mount Sinai Hospital School of Nursing caps. The collection include a shipboard newsletter from the U.S.S. Repose and a hospital newspaper from Thomas M. England General Hospital, locations where Shapiro served.

The physical album consists of 75 pages of photographs taken at St. Luke's Hospital between 1914 and 1917, by Dr. Norman Titus. It appears that many of the images were taken on the roof-top patio of the Travers Pavilion, and views of the Cathedral of St. John the Divine are sometimes visible. Most of the images are of medical staff - doctors, nurses and student nurses, though some young patients are included, as are few general ward images. Some of the images are labeled with places or names, but not all.

Dr. Titus was a member of the House Staff, starting in Pathology in 1914 and moving to 6 month rotations in Ear, Nose & Throat, Surgical, and Medical services through 1917. It might be of interest to note that fellow house staff colleagues in the Pathology Department Andrew Peters, Jr. MD, Robert Emmet Sribels, MD, George N. Acker, MD, and Frank D. Scudder, MD are often the subject of his photographs.