In this interview Dr. Kotler talks about his childhood influences and interest in medicine, his schooling and his desire to not be a only a scientist but an academic physician; his early research that became heavily HIV-based and experiences around that research and patient care; he also touches on the subjects of changes in medical practice and equipment; writing grants and journal articles and those challenges, and comments on the changing names of Mount Sinai Health System hospitals. He mentions the following names: Drs. Russ Gaetz, Bill Ramey, John Scholes, Fred Clayton, Mike Lange, Yori Inada, Michael Greico, Michael Lange, Peter Holt, Mary O’Sullivan, Joe Sonnabend, Richard Pierson, Steve Heymsfield, Jack Wang, Anthony S. Fauci, Sami Hashem, Jan Orenstein, John H. Keating, Ted Van Itallie, Carl Hoffman, Jim Fingerhut, and George Cahill.