Peter R. Holt, MD, is the physician responsible for establishing the Department of Gastroenterology at St. Luke’s Hospital, and served as its Chief from 1962-2000. In this interview he briefly mentions his childhood in Berlin, Germany and England during WWII, his decision to further his medical studies in the US, finding his way to St. Luke’s Hospital almost accidently. He discusses his fellowship at Massachusetts General Hospital in Boston, his early research, moving into gastroenterology, and his return to St. Luke’s. He touches on the general culture of St. Luke’s in the 1960s-1970s, for example encouraging nursing staff to join patient rounds, the hospital mergers under Continuum Health Partners, his eventual decision to leave St. Luke’s, and the positions he has held at the American Health Foundation, The Strang Cancer Prevention Center, and his current post at the Rockefeller University. He mentions interactions with the following colleagues: G. Jarvis Coffin, MD; Robert B. Case, MD; Richard N. Pierson, MD; John H. Keating, Sr., MD; Theodore B. VanItallie, MD; Kurt J. Isselbacher, MD; Charles A. Flood MD; Miles J. Schwartz, MD; Richard S. McCray, MD; David Chalfin, MD, PhD; Steven Mezey, MD; Stanley E. Bradley, MD; Norton Rosenzweig, MD; Steven Moss, MD; Albert Attia, MD; and Harry A. Roselle, MD.