The collection is organized into three series: Medical Subject Files, General Subject Files, and Research Notebooks. Medical Subject Files contains Dr. Hodes' files on medical topics, the majority of them related to his specialties of pediatric bacteriology and virology. Files typically contain a mixture of correspondence, manuscripts and research material related to a particular disease, syndrome or chemical compound. Of particular note are the files related to Dr. Hodes' study of infant diarrhea and the extensive collection of papers related to polio, which include the records of his service on the Congressional panel that testified to the efficacy of the Salk Vaccine. Many subject files contain manuscript material received from other researchers. Major manuscripts by Mount Sinai staff have been identified. General Subject Files includes professional association records, personal correspondence, and material relating to Dr. Hodes' employment at Mount Sinai. They document Dr. Hodes' term as President of the American Pediatric Society, his service on the executive committee of the Mount Sinai Physicians' Practice Association, and many other activities. The series contains correspondence with numerous major figures in the history of Mount Sinai as well as with distinguished colleagues at other institutions. It includes correspondence with his brother Robert and son David, both of whom worked at Mount Sinai. The Research Notebooks series contains eight research notebooks dating from the early 1950s which document experiments carried out on laboratory animals.