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The American College of Surgeons was the accrediting body for hospitals until the Joint Commission on the Accreditation of Hospitals was created in 1951.

Astoria General Hospital was established in 1949. The hospital was originally located in a building that had been built in 1895 to house the (institutionally unrelated) Astoria Hospital

The Beth Israel Hospital was founded in New York City in 1889. Initially established to serve the Lower East Side's growing population of Eastern European Jewish immigrants, the Hospital grew into a major charitable hospital serving patients of all backgrounds. In the 1890s it was based out of existing structures on the Lower East Side, but in 1902 the Hospital moved to a purpose-built hospital building on Jefferson and Cherry Streets, and in 1929 it relocated to its present location on East 17th Street. In the ensuing years the Hospital affiliated with numerous other medical institutions and expanded its 17th Street campus through the construction of new buildings and the purchase of adjacent structures, including the neighboring Manhattan General Hospital. In 1965 the institution was renamed the Beth Israel Medical Center to reflect this growth. In 1997, Beth Israel joined several other New York City hospitals in the establishment of Continuum Health Partners, a multi-hospital system. Following the merger of Continuum Health Partners and The Mount Sinai Medical Center in 2013, Beth Israel became a part of the newly established Mount Sinai Health System. It was renamed Mount Sinai Beth Israel the following year.

The Beth Israel Hospital was founded in New York City in 1889 and opened its first inpatient location in 1891. Initially established to serve the Lower East Side's growing population of Eastern European Jewish immigrants, the Hospital grew into a major charitable hospital serving patients of all backgrounds. In the 1890s it was based out of existing structures on the Lower East Side, but in 1902 the Hospital moved to a purpose-built hospital building on Jefferson and Cherry Streets. Construction on the Dazian Pavilion, the first building of Beth Israel's main campus on 17th Street on Stuyvesant Square, began in 1922. The building was completed in 1929. In the early 1930s Beth Israel affiliated with the Jewish Maternity Hospital, and in 1946, following the gradual absorption of the Maternity Hospital by the obstetrics department of Beth Israel, the two institutions were legally consolidated into a single entity under the Beth Israel Hospital Association name. In the ensuing years the Hospital affiliated with numerous other medical institutions and expanded its 17th Street campus through the construction of new buildings and the purchase of adjacent structures. In 1965, following Beth Israel's acquisition of the neighboring Manhattan General Hospital, the institution became known as the Beth Israel Medical Center. In 1997, Beth Israel merged with St. Luke's-Roosevelt Hospital Center and the Long Island College Hospital to form the Greater Metropolitan Health System, whose name was changed to Continuum Health Partners in 1998. Following the merger of Continuum Health Partners and The Mount Sinai Medical Center in 2013, Beth Israel became a part of the newly established Mount Sinai Health System. It was renamed Mount Sinai Beth Israel the following year.

The Board of Directors of the Beth Israel Hospital Association was established in 1889 and formally chartered by New York State the following year for the purpose of creating a hospital to serve the growing Lower East Side Jewish community while maintaining orthodox dietary and religious laws. At some point between 1924 and 1927 the Board of Directors was renamed the Board of Trustees. In the early 1930s Beth Israel affiliated with the Jewish Maternity Hospital, and in 1946, following the gradual absorption of the Maternity Hospital by the obstetrics department of Beth Israel, the two institutions were legally consolidated into a single entity under the Beth Israel Hospital Association name. In 1965, following Beth Israel's acquisition of the neighboring Manhattan General Hospital, the institution became known as the Beth Israel Medical Center. In 1997, Beth Israel merged with St. Luke's-Roosevelt Hospital Center and the Long Island College Hospital to form the Greater Metropolitan Health System, whose name was changed to Continuum Health Partners in 1998.

"The Church of the Holy Communion was a member of the Protestant Episcopal denomination. It was the first church in NYC to do away with charging a pew rental fee, encouraging the rich and poor to worship together, and it was one of the first to offer a weekly communion service The building's construction was funded by Mrs. Mary Muhlenberg Rogers, who wished to fulfill the request of her late husband to build a church in the city ‘where rich and poor might meet together,' and that her brother, the Rev. William A. Muhlenberg would pastor. The Gothic Revival church, located at West 20th Street and Sixth Avenue, was designed by Richard Upjohn. It was built between 1844 and 1846 and was consecrated in 1846. In 1850 Upjohn added a rectory and parish house, and designed the Sister's House in 1853.

Rev. Muhlenberg was especially conscious of the poor in the surrounding areas and offered many ministry outreaches to them through the church. Early in the life of the community, a small group of faithful women gathered to devote their lives to supporting this arm of the church's work. Calling themselves a Sisterhood, as they wished to distance themselves from Roman Catholic practice, they based their ideals on a group of Lutheran Deaconesses from Kaiserswerth, Germany who served the church there by nursing and teaching. The Sisterhood was formally incorporated in 1851, though the first to make her vows, Anne Ayres, did so in 1845. They ran a girls' school for a time, and in 1853 opened a small 15-bed infirmary in the house next door to theirs. The Infirmary was often called the “Little St. Luke's,"" or “Infant St. Luke's,"" and it was referred to as such by the Landmarks Preservation Commission, which conferred landmark status to the church buildings in 1966.

When St. Luke's Hospital opened in 1858, the Sisters acted as the head nurses, with Sister Anne as House Matron over them and non-medical hospital staff. Their work was closely tied to the organization of the hospital, and Sister Anne was second-in-command to Rev. Muhlenberg and worked closely with him through their lives. In 1876 the Trustees gave her the title, “Sister-Superintendent"" with powers co-ordinate with those of Rev. Muhlenberg. As nursing, teaching and other welfare functions the Sisters initially provided developed into their own separate professions, the numbers of the Sisterhood, which was never a very large group, declined and it ceased with the death of its last members in 1934.
Rev. Muhlenberg died April 8, 1877 and was buried in the cemetery of St. Johnland's Convalescent Home, another work he founded to care for disabled children and the elderly on the north shore of Long Island. Sister Anne retired after his death and spent her time organizing his papers, editing the two volume work by Muhlenberg titled The Evangelical Catholic Papers, and writing a biography of Muhlenberg. In 1896 she assisted with the move of St. Luke's Hospital to its new home at 113th St., caught a severe case of bronchitis, and died a few weeks later, at the age of 80 years. She is buried in St. Johnland's cemetery, next to Rev. Muhlenberg.

By the mid-20th century the area around the church had become highly industrialized and the congregation began to decrease in size. In 1976, the congregations of the Church of the Holy Communion, Calvary Church, and St. George's Church, all of which were struggling with shrinking memberships, merged, and formed the Calvary-St. George's Parish, two churches which meet at Gramercy Park and Stuyvesant Square Park. The Church of the Holy Communion's building was deconsecrated and sold to the Odyssey Institute, which used it as a drug rehabilitation facility. In 1983, the Odyssey Institute sold the building to Peter Gatien, who recreated it as The Limelight disco. Becoming notorious as a drug market place, The Limelight was closed in 1996. Since then, the building interior (the exterior was landmarked in 1966) has been re-created as an art studio, a shopping mall, a restaurant and a fitness club."

In 1997, the Beth Israel Medical Center merged with St. Luke's-Roosevelt Hospital Center and the Long Island College Hospital to form the Greater Metropolitan Health System, Inc., which was renamed Continuum Health Partners in 1998. In 1999, the New York Eye and Ear Infirmary joined Continuum. Long Island College Hospital withdrew from the corporation in 2011. Continuum Health Partners merged with The Mount Sinai Hospital and Mount Sinai School of Medicine in 2013 to form the Mount Sinai Health System.

The Dazian Foundation for Medical Research was created by the estate of Henry Dazian. His will stated that the mission of the Foundation was to have as "its fundamental and primary purpose the advancement of medical and allied scientific knowledge." A further definition of its objects and purposes is set forth in directions that the income be applied in part (1) for the creation of fellowships "to consist of post-graduate education along specialized lines in some science or subject directly or indirectly associated with medical science for persons already possessing a degree of doctor of medicine," and (2) in making contributions "to laboratories, hospitals or similar institutions not operated for profit, to be used in research or investigation for the advancement of medical or allied scientific knowledge." Many of the individuals on the Board of the Foundation were members of the Medical Staff of The Mount Sinai Hospital, and former members of the Hospital house staff received Fellowships. The Foundation supported Fellows in Latin American countries and some Fellows later went on to win Nobel Prizes.

Doctors Hospital was a voluntary hospital on the Upper East Side of New York City which catered to affluent private patients. It was located at 170 East End Avenue between 87th and 88th Streets, overlooking Carl Schurz Park and Gracie Mansion.

The hospital was founded in the late 1920s by a group of socially prominent doctors and investors to meet the growing demand for private hospital rooms. Hospitals, by this time, had replaced the home as the primary site of medical treatment for patients of all social classes, but New York City's hospitals had a limited supply of rooms for affluent patients who did not want to be housed on public wards.

The cornerstone of the hospital building was laid on April 30, 1929, and the hospital opened to patients on February 19, 1930. On its opening, the fourteen-story building contained 264 private rooms, with an additional 32 hotel-like rooms in which patients' relatives could stay during treatment. It had no wards. Nicknamed the “hotel hospital" for its lavish interiors, its rooms were decorated in an early American style and included conveniences such as private iceboxes, which aimed at replicating the comforts of home for its wealthy patients. The founding medical staff of the hospital consisted of 182 doctors and surgeons.

The hospital was founded as a for-profit corporation and was expected to yield a return for its shareholders. In 1932, however, the shares of the hospital were turned over to a charitable foundation and the hospital was reorganized as a voluntary institution. Many believed this decision to have been motivated primarily by tax purposes. In 1941 the city brought a suit against the hospital for payment of back taxes, arguing that because it catered to private patients and did not offer charity care, it was not entitled to the hospital property tax exemption. The State Supreme Court ruled in favor of the city, but the ruling was overturned by the Appellate Division in 1944, which held that the exemption applied equally to all voluntary hospitals regardless of their patient demographics. Throughout the middle decades of the twentieth century the hospital continued to serve New York's social elite as a place for medical treatment in a genteel private setting.

From its founding until its acquisition by Beth Israel in 1987, Doctors Hospital was governed by a Board of Directors. Following the acquisition, this body was reorganized as a Board of Trustees, and in 1992 it was renamed the Board of Trustees of Beth Israel Hospital North.