Charlotte Friend, PhD papers

Identity elements

Reference code

US AA034

Name and location of repository

Level of description

Collection

Title

Charlotte Friend, PhD papers

Date(s)

  • 1935-1987 (Creation)

Extent

44 boxes (222 inches)

Name of creator

(1921-1987)

Biographical history

Charlotte Friend was a noted microbiologist who made important contributions to the study of cancer. She was born March 11, 1921 in New York City, a city she loved. She received a Bachelor's degree from Hunter College in 1944. She then entered the Navy where she was assigned to help direct a hematology laboratory in California. When she left the Navy in 1946, she began graduate work in microbiology at Yale University. By the time she received her doctorate in 1950, Dr. Friend already had a position in the laboratory of Dr. Alice Moore at the Sloan-Kettering Institute in New York City. In 1956, Dr. Friend gave a paper at the annual meeting of the American Association for Cancer Research in which she stated that she had discovered a virus that caused a leukemia-like disorder in newborn mice. She was roundly criticized for bringing up what was considered to be the old canard of viruses causing cancer. But the tide of change on this issue was turning in the face of mounting evidence. Dr. Friend spent the following years investigating different aspects of the virus, as did many other researchers. She worked with various collaborators, often cooperating in international research efforts. Dr. Friend loved to travel and formed many long-term friendships with colleagues in Europe. Her sabbatical years (1963 and 1975) were spent in laboratories in Australia, Israel, France and Italy. She also attended many international meetings. Dr. Friend was very active in various associations and in outside professional activities such as grant reviewing and serving on editorial boards and advisory councils. In the 1970s, when many associations 'discovered' their female members, Dr. Friend was asked to assume leadership roles in several organizations including: chairman of the Gordon Conference (1973); member of the Board of Directors (1973-76) and president (1976) of the American Association for Cancer Research; president of the Harvey Society (1978/79); and president of the New York Academy of Sciences (1978). In 1966, Dr. Friend left Sloan-Kettering to become the first Director of the Center for Experimental Cell Biology and a Professor at the still developing Mount Sinai School of Medicine. She was the first and only female full Professor in School when the faculty was formed in 1966. She also was a Professor in the Graduate School of Biological Sciences. At Mount Sinai, she established her own laboratory that in 1967 was endowed as the Mollie B. Roth Laboratory. Still, there was an unending struggle to find the funding to keep the lab well staffed and well equipped, a situation that got harder as federal funding began to shrink in the 1970s. The decline in federal funds for basic research led Dr. Friend to write several protest letters to congressmen and others in power. This was a tact that she often took when a subject that mattered to her was threatened. She wrote about many things, including support for Israel, against anti-abortion measures, and in defense of women's rights. In 1971, Dr. Friend published another landmark paper, this one titled "Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethyl sulfoxide." The co-authors were William Scher, J.G. Holland and Toru Sato. This paper described research on leukemia cells that had been made to differentiate, or take another step in the maturation process to become erythroid cells, thus stopping their cancer-like multiplication. Research continues today by many others in the field trying to make this a reality in cancer care. Dr. Friend was unusual in having made two major contributions during her career. In all, she published 163 papers, 70 of which she wrote by herself or with one other author. Although diagnosed with lymphoma on her 60th birthday in 1981, she told few of her illness. She continued to go about her work with all the energy she had, writing grants, serving on committees, and working in the lab. Charlotte Friend died in January 1987.

Content and structure elements

Scope and content

The Charlotte Friend collection provides an excellent view of the scientist as well as the non-research side of a researcher's career. These files document Dr. Friend's role as a professional involved with numerous organizations as a leader, committee member, and reviewer; as an administrator of her own lab, with the concomitant need to write and receive grants from outside funding; and, at a lessening degree as time went on, as a teacher. Dr. Friend's research efforts are harder to trace here. The natural source for this would be the research notebooks, but these are now lost, with only a few remaining in the Center for Experimental Cell Biology. In this collection, the Manuscripts Series has the finished product of this research, although this series ends in 1979. There is also the Meetings, Speeches and Notebooks Series, which shows somewhat the progress of her work. Scattered throughout the Correspondence and Alphabetical series are also fleeting references to her work. There is also a small set of glass lantern slides from 1956-1963 (Box 44) that show experimental mouse specimens and cells. These were contained in a slide box with the initials C.P.R. on the top. It seems likely that the box once belonged to Cornelius P. Rhoads, who served as Director of Memorial Hospital from 1940-1953 and was the founding Director of Sloan Kettering Institute, where he served until his death in 1959. Another facet of the collection is the insight it provides into the world of cancer research during an important era, an era which Dr. Friend herself helped propel. This was the time, starting in the 1950s, when scientists gradually turned to an acceptance of viruses as cancer causing agents in humans. The evolution of the field may be traced through the conference programs (Box 33-38), the journal articles that Dr. Friend reviewed (Box 2, Box 7-19), as well as through the correspondence and her own research. These papers also show the intimacy of the cancer research community itself, at least at the level at which Dr. Friend operated. These papers provide information on women's role in science. Dr. Friend in some ways held an unusual position. Her discovery of the Friend leukemia virus established her reputation very early in her career. Perhaps because of this, she felt that she herself was not held back by being a woman, with the exception of some wage discrimination. Still, she believed that science truly had been a man's world and that it would take conscious and steady efforts by women to change this. For her part, this involved nominating women to positions of authority in organizations; suggesting women speakers for programs; speaking out about women's issues; serving as a role model to young women from grade school to graduate school; and ultimately, by taking time from her own lab to serve in prominent positions in professional associations. The latter is reflected in the Alphabetical Series in files on the Harvey Society, the American Association for Cancer Research, the New York Academy of Sciences, and the National Academy of Sciences. Finally, the Charlotte Friend Papers give a great deal of insight into her as a person. She cared deeply about and was very involved with her family (Personal Series). She loved to travel, but always loved New York. She wrote letters to congressmen and mayors on issues she cared about, including support for Israel, cuts in research funding, the status of women, and abortion rights (Box 42, f.7). Her support staff loved her, and many times she functioned as a mother hen to the group. Still, she seemed to be the mentor to few graduate students, and colleagues did not remain many years in her lab. She was a complex woman whose intricacies are clearly displayed in this collection.

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Conditions of access and use elements

Conditions governing access

  • This material may be closed for a minimum of 25 years from creation, depending on their content, and access may further be restricted due to the presence of HIPAA-protected Personal Health Information. Please contact the Archives (MSArchives@mssm.edu) for additional information.
  • There are a few restricted and closed files in this collection. [NB The restrictions on pre-publication reviews have been lifted due to the passage of time, 5/06.] The restrictions generally relate to personal or institutional information in the files. They are available for research at the discretion of the Archivist, based upon the intended uses of the researcher. The closed files are not available for use due to the private information in the files. They will be opened as soon as possible in consonance with the rights of the individuals involved.

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Technical access

Conditions governing reproduction

Languages of the material

  • English
  • French

Scripts of the material

    Language and script notes

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    Generated finding aid

    Acquisition and appraisal elements

    Custodial history

    This collection was created by combining donations from Mr. Morris Friend (March 1987 and July 1991), Dr. Friend's brother, with later accessions from Dr. Beatriz Pogo of Dr. Friend's laboratory (June-August 1987, January 2008). Mr. Friend's gifts form the bulk of the Personal Series.

    Immediate source of acquisition

    Appraisal, destruction and scheduling information

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    Specialized notes

    Alternative identifier(s)

    Legacy ID from CMS

    AA.000223

    OCLC Number

    237792778

    Description control element

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    Sources used

    Archivist's note

    Processed by Barbara Niss in 1990-1991. Revised in 1/2008 and 12/2017.

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